The Relationship Between Dietary Lipids and Serum Visfatin and
Adiponectin Levels in Postmenopausal Women
Endocrine, Metabolic & Immune Disorders - Drug Targets
2014, 14
ISI
Ali R. Rahbar,and Iraj Nabipour
دریافت فایل پیوست
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Relationship among plasma adipokines, insulin and androgens level as
well as biochemical glycemic and lipidemic markers with incidence of
PCOS in women with normal BMI
Gynecological Endocrinology
2012; 28(7)
ISI
دریافت فایل پیوست
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Comparative effects of red and white grapes on
oxidative markers and lipidemic parameters in
adult hypercholesterolemic humans
Food & Function
2015 Jun;6(6):1992-8.
ISI
Ali Reza Rahbar, Mohammad Mehdi Shakouri Mahmoudabadi and Md. Shahidul Islam
First of three
The present study compared the effects of consuming red versus white whole grapes on oxidative and
lipidemic indices in people with hypercholesterolemia. Sixty nine patients were randomized into three
groups. The two treatment groups consumed 500 g of either Condori red grapes or Shahroodi white
grapes daily for 8 weeks, and the third group served as a control. Plasma glucose, triacylglycerol (TG),
cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C),
thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) were determined by
colorimetric methods at baseline and at the end of the study. In addition, the polyphenol and fiber
content of the two grape varieties was measured. TBARS was reduced in both study groups compared to
the control group, and the reduction was greater in the group that consumed red grapes compared to
the white grapes. TAC was increased significantly in both red and white grape consuming groups compared
to the control group. Total cholesterol and LDL-C were decreased in the red grape group compared
to the control group. No significant changes in fasting blood glucose, TG or HDL-C were observed
among the groups. The results of this study suggest that consumption of the whole fruit of red grapes has
more potent anti-oxidative and hypolipidemic effects compared to the white grapes in hyperlipidemic
adult humans. Hence, the whole fruit of red grapes may be an excellent fruit choice not only to prevent
oxidative stress related metabolic disorders but also cholesterol related cardiovascular diseases, particularly
in hyperlipidemic adult humans.
Cite this: DOI: 10.1039/c5fo00100e
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Effect of EPA and vitamin C on superoxide dismutase, glutathione peroxidase,total antioxidant capacity and malondialdehyde in type 2 diabetic patients
Oman Medical Journal
2014 29 (1), pp. 39-45
Scopus
Authors of DocumentShakouri Mahmoudabadi, M.M., Rahbar, A.R.
Second of two
Objectives: The aim of this study is to investigate the effect of eicosapentaenoic acid combined with vitamin C in comparison with the pure form of eicosapentaenoic acid on the serum concentration of malondialdehyde, erythrocyte activity of superoxide dismutase, glutathione peroxidase, and the serum level of total antioxidant capacity in patients with type 2 diabetes. Methods: Eighty one male diabetic patients, aged 33-63 years, were randomly assigned to one of 4 groups. The subjects consumed 500 mg/d pure eicosapentaenoic acid, 200 mg/d vitamin C, 500 mg eicosapentaenoic acid and 200 mg/d vitamin C or placebo depending on their groups. In fasting blood samples, superoxide dismutase and glutathione peroxidase activities were determined via the enzymatic method (Randox kit) and the serum total antioxidant capacity, malondialdehyde and vitamin C concentrations were estimated by colorimetric methods. Results: Administration of pure eicosapentaenoic acid in diabetic patients increased superoxide dismutase by 4%, glutathione peroxidase 53%, total antioxidant capacity 36% and decreased malondialdehyde significantly by 25%. Prescription of eicosapentaenoic acid combined with vitamin C demonstrated a significant increment for superoxide dismutase activity by 3% and for glutathione peroxidase activity by 52% during the study, but no significant change was seen for total antioxidant capacity and malondialdehyde, respectively. There was a significant decrease in FBS and HbA1c following prescription of eicosapentaenoic acid with/without vitamin C along the study, although these changes were not significant between the study groups. Conclusion: It is concluded that prescription of eicosapentaenoic acid in the pure form reduces oxidative stress in type 2 diabetic patients; albeit, it does not alleviate hyperglycemia. Combination of vitamin C and eicosapentaenoic acid does not improve antioxidant property of eicosapentaenoic acid. © OMSB, 2014.
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The hypolipidemic effect of citrullus colocynthis on patients with hyperlipidemia
Pakistan Journal of Biological Sciences
2010, 13 (24), pp. 1202-1207
Pubmed
Rahbar, A.R., Nabipour, I.
First of two
Chronic, low-grade metabolic acidosis due to Western diets may be a risk factor for osteoporosis. The severity can be determined in part by net endogenous acid production (NEAP). In a population-based study, a total of 1028 healthy men and women aged 20-72 years were evaluated for dietary intakes and NEAP estimates with a validated food frequency questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to determine BMD of the lumbar spine (L2-L4), distal third of radius, and proximal femur. Serum CrossLaps, degradation products of the C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific ELISA methods. Lower estimates of energy-adjusted rates of NEAP were associated with greater femoral neck BMD (p = 0.01) in premenopausal women and with greater BMDs at the distal radius (p = 0.001) and lumbar spine (p = 0.04) in postmenopausal women. Compared with women in the highest quartile of the estimates of the energy-adjusted rates of NEAP, pre- and postmenopausal women in the lowest quartile had significantly greater means of osteocalcin [9.12 (SD ± 1.62) vs. 5.24 (SD ± 1.41) ng/ml, p = 0.02 and 11.74 (SD ± 1.69) vs. 7.79 (SD ± 2.63) ng/ml, p = 0.002, respectively]. Analysis by quartiles of the estimates of energy-adjusted rates of NEAP did not reveal a relationship between BMD and bone turnover markers in men. In conclusion, we found that a high energy-adjusted rate of NEAP was associated with a significantly lower BMD in women but not in men and the energy-adjusted rate of NEAP had a negative relationship with bone formation. © 2009 Elsevier Inc. All rights reserved.
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Effects of omega-3 fatty acids on serum lipids and high sensitivity C reactive protein in cigarette smokers
Journal of Biological Sciences
2007, 7 (8), pp. 1368-1374
Pubmed
Rahbar, A.R., Nabipour, I., Amiri, Z.
First of three
The aim of this study was to determine the impact of omega-3 fatty acids on lipid metabolism and low-grade inflammation in cigarette smokers. In a double-blind, placebo-controlled trial, 59 male cigarette subjects were randomly assigned to consume 3 g omega-3 fatty acids or com oil/day for 8 weeks while continuing to consume their usual diet. High sensitivity C reactive protein (hs-CRP) was determined by ELISA. Fifty-one subjects completed the study. Neither omega-3 fatty acids nor com oil supplementation had a significant effect on triglyceride, HDL-cholesterol or total cholesterol concentrations. After adjustment for baseline values, fasting LDL-cholesterol concentrations increased 16.7% with omega-3 fatty acids supplementation (p<0.05) in comparison with the change in the com oil group. The intervention caused no significant changes serum hs-CRP concentrations. In conclusion a daily intake of omega-3 fatty acids increases LDL-cholesterol by 8% in cigarette smokers and had not effects on serum triglyceride and hs-CRP concentrations. © 2007 Asian Network for Scientific Information.
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Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitu
European Journal of Clinical Nutrition
2005, 59 (4), pp. 592-596
ISI
Rahbar, A.R., Shakerhosseini, R., Saadat, N.,, Pordal, A., Gollestan, B.
First of five
Objective: We designed this study to investigate the effects of oral L-carnitine administration on fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and lipid parameters in patients with diabetes mellitus type II. Patients and methods: The effect of L-carnitine on FPG and lipid parameters was investigated in 22 male and 13 female type II diabetic patients; the mean age ± s.d. was 51.3 ± 3.7 y. The patients were randomly allocated to two groups (L-carnitine and placebo group) and 1 g of L-carnitine or of placebo was given orally three times a day for a period of 12 weeks. Results: FPG in the L-carnitine group decreased significantly from 143 ± 35 to 130 ± 33 mg/dl (P = 0.03), and we observed a significant increase of triglycerides (TG) from 196 ± 61 to 233 ± 12 mg/dl (P = 0.05), of Apo A1 from 94 ± 20 to 103 ± 23 mg/dl (P = 0.02), and of Apo B100 from 98 ± 18 to 108 ± 22 mg/dl (P = 0.02) after 12 weeks of treatment. There was no significant change in LDL-C, HDL-C, HbA1C, LP(a) or total cholesterol. Conclusion: L-Carnitine significantly lowers FPG but increases fasting triglyceride in type II diabetic patients. © 2005 Nature Publishing Group All rights reserved
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Effective removal of Hg2+ from aqueous solutions and seawater by Malva sylvestris
Desalination and Water Treatment
2016 pp. 1-13
ISI
Ramavandi, B., Rahbar, A., Sahebi, S
Second of three
This paper introduces a biomaterial prepared from Malva sylvestris for environmental remediation and medicine treatment purposes. The effects of pH (2–12), adsorbent dose (0.1–1.25 mg/L), Hg2+ concentration (5–15 mg/L), and contact time (3–60 min) were studied on the removal of Hg2+ from aqueous phase. The results were compared with powder of charcoal tablet, a medicine drug. At pH solution of 8, over 96% removal of 10 mg/L Hg2+ was obtained for a M. sylvestris powder (MSP) dose of 1.5 mg/L after a 40 min contact time; while for these conditions only 60% of Hg2+ was removed by charcoal tablet powder (CTP). The Langmuir model was the best fit for the experimental data, which attains a maximum adsorption capacity of 602 and 389 mg/g for MSP and CTP, respectively. Surface analyses (Fourier transform infrared, scanning electron microscopy, Brunauer, Emmet, and Teller, and X-ray photoelectron spectroscopy) of the MSP were also performed. The co-adsorption study indicated that the Hg2+ adsorption by MSP was 33% increased by addition of 2 mg/L ceftriaxone antibiotic. The MSP had acceptable performance after four times recycling. The MSP could be used to remove Hg2+ ions from seawater. Accordingly, the finding of this work suggests that the prepared adsorbent, MSP, is an efficient, no-cost, and promising biomaterial for the removal of Hg2+ ion from liquid phase and could be substituted for charcoal tablets in medicine.
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The relationship between ferritin and anemia parameters in females with iron deficiency anemia and inflammation
Jordan Medical Journal
2015, 49 (4), pp. 205-214
Scopus
Rahbar, A.R., Safavi, E
First of two
Objective: Iron deficiency is the leading cause of anemia worldwide, and measuring serum ferritin concentration is recognized as the gold standard test for iron deficiency anemia. In inflammation, however, hyperferritinemia occurs without evidence of iron overload. The aim of this study was to investigate the relationship between ferritin and other anemia parameters in female patients with a combination of iron deficiency anemia and inflammation. Methods: A total of 314 girls and women with anemia (Hb <12.5 g/dL) were selected from users of primary health care centers in Shif port. The participants were divided into a study and a control group. The study group included females with anemia and inflammation, and the control group included anemia without inflammation. Complete blood count, serum ferritin, iron and hemoglobin concentration, hematocrit, mean cell volume, mean cell hemoglobin concentration, red cell distribution width, transferrin saturation, total iron binding capacity and C-reactive protein were measured by autoanalyzer and ELISA kits. The relationship between ferritin and hemostatic markers was estimated with Pearson's correlation coefficient and multiple linear regression models. Results: There was a significant positive correlation between serum ferritin and serum iron concentration, hemoglobin, hematocrit and mean cell hemoglobin concentration before and after adjustment for age in both groups. A negative association between serum ferritin level and total iron binding capacity was also found in both groups. Conclusions: We conclude that ferritin is a reliable noninvasive standard test to diagnose iron status in females with iron deficiency anemia even in the context of inflammation.
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The Effect of Stevia Rebaudiana on Serum Omentin and Visfatin Level in STZ-Induced Diabetic Rats
ournal of Dietary Supplements
2015, 12 (1), pp. 11-22
Pubmed
Akbarzadeh, S., Eskandari, F., Tangestani, H.,, O'Connor, W.J., Rahbar, A.R
Fifth of five
Recently the role of adipocytokines in relationship to incidence of diabetes has been demonstrated. One of the medicinal plants that are used in the treatment of diabetes is stevia. This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). The animals were divided into 5 groups of 8. Rats in group 1 (non-diabetic control) and group 2 (diabetic control) were treated with distilled water, and the rats in the treated groups, group 3 (T250), group 4 (T500), and group 5 (T750) were treated with stevia, gavaged every day at 9 a.m. in doses of 250, 500, and 750 mg/kg, respectively. At the end of the study significant reductions in fasting blood sugar (FBS), the homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), alkaline phosphatase (ALP), and Omentin level were found in groups 3 and 4 in comparison with group 2. Pancreatic histopathology slides demonstrated that stevia extract did not induce any increase in the number of β-cells. The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats.
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Relationship among sera lipoprotein abnormalities in healthy individuals with background of diabetic sibling
Source of the Document African Journal of Biotechnology
2011 10 (48), pp. 9904-9907
ISI
Authors of DocumentAkbarzadeh, S., Ghasemi, S., Kalantarhormozi, M., Mirzaei, M., Rahbar, A.R.
Fifth of five
Polycystic ovary syndrome (PCOS) is an endocrine disorder in women. Omentin-1 and vaspin are secretary adipokines that are produced by the visceral adipose tissue. These levels change in obese women with PCOS. The aim of this study is to investigate whether omentin and vaspin levels change in nonobese PCOS subjects. This study is a cross-sectional case control study in which 39 women with PCOS were picked out for this study. The inclusion criteria were based on the Rotterdam 2003 diagnostic criteria. The control group consisted of 39 women with normal pelvic sonographic reports having regular menstruation and showing no signs of infertility. The fasting plasma glucose (FPG), triglyceride (TG), Chol, and high-density lipoprotein cholesterol (HDL-C), insulin, testosterone, omentin and vaspin were measured by the enzymatic methods. The differences within these groups were calculated by the un-paired t-test and the MannWhitney test. The results from this study show a significant increase in the amount of insulin, testosterone, homeostasis model assessments for insulin resistance, TG and lower HDL in the patient group. No significant differences were seen in omentin, vaspin, FPG, Cho, low-density lipoprotein, very low-density lipoprotein cholesterol, blood urea nitrogen, Cr and homeostasis model assessments for B cell function levels between groups. Results show that PCOS is not a determinant of decreased omentin and vaspin plasma levels and those high androgen level and insulin resistances are warning signs of PCOS.
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Relationship among dietary estimates of net endogenous acid production, bone
mineral density and biochemical markers of bone turnover in an Iranian
general population
Bone
876–881 :45 2009
ISI
Alireza Rahbar , Bagher Larijani , Iraj Nabipour , Mohamad Mehdi Mohamadi , Kamran Mirzaee , Zahra Amiri
First of five
Chronic, low-grade metabolic acidosis due toWestern diets may be a risk factor for osteoporosis. The severity can be determined in part by net endogenous acid production (NEAP). In a population-based study, a total of
1028 healthy men and women aged 20–72 years were evaluated for dietary intakes and NEAP estimates with
a validated food frequency questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to determine BMD of the lumbar spine (L2–L4), distal third of radius, and proximal femur. Serum CrossLaps, degradation products of the C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific
ELISA methods. Lower estimates of energy-adjusted rates of NEAP were associated with greater femoral neck BMD (p=0.01) in premenopausal women and with greater BMDs at the distal radius (p=0.001) and lumbar
spine (p=0.04) in postmenopausal women. Compared with women in the highest quartile of the estimates of the energy-adjusted rates of NEAP, pre- and postmenopausal women in the lowest quartile had significantly greater means of osteocalcin [9.12 (SD±1.62) vs. 5.24 (SD±1.41) ng/ml, p=0.02 and 11.74 (SD±1.69) vs. 7.79 (SD±2.63) ng/ml, p=0.002, respectively]. Analysis by quartiles of the estimates of energy-adjusted rates of NEAP did not reveal a relationship between BMD and bone turnover markers in
men. In conclusion, we found that a high energy-adjusted rate of NEAP was associated with a significantly lower BMD in women but not in men and the energy-adjusted rate of NEAP had a negative relationship with bone formation
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Plasma concentration of acylated ghrelin in patients with Alzheimer’s disease
African Journal of Biochemistry Research
2013, 7(1), pp. 8-12
Embase
Akbarzadeh S, Yusefi F, Jafari SM, Khosravizadegan F, Moula A, Salimipour H, Eghbali SS, Motamed N, Hajian N, Rahbar A, Abdi MR, Hazrati S and Movahed A
Tenth of therteen
Ghrelin is a hormone produced in the stomach and tightly linked to the regulation of energy balance and cognitive processes. It may be altered in Alzheimer’s disease (AD), a dementia syndrome markedly influenced by metabolic diseases. The aim of this study was to evaluate the changes in the plasma concentration of acylated ghrelin in patients with AD. The study included 71 people 37 in the case Group (23 female, 14 male) with AD and 34 controls (20 female, 14 male). The clinical symptoms of the patients based on the DAM-IV criteria were registered and cognitive function was assessed with the mini mental state exam (MMSE) which measures the severity of AD. The plasma concentration of acylated ghrelin, glucose, lipids and lipoproteins were measured by using ELISA assay kits and enzymatic methods. The plasma concentration of acylated ghrelin was significantly higher in the group with Alzheimer’s disease compared with the controls and it was not associated with the biochemical parameters including glucose, lipids and lipoproteins. The results of the current study show higher plasma concentrations of AG in the people with Alzheimer’s disease, and it was not associated with changes in anthropometric characteristics, plasma lipids and lipoproteins of the patients. This suggests that as a preliminary work, it could be helpful for the follow up of the disease, but more investigations are required to clarify the issue.
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بررسي اثر دانه گياه اسفرزه بر ميزان سطوح تريگليسيريد و ليپو پروتئينهاي سرمي
مجله طب جنوب
مجله طب جنوب ، سال يازدهم، شماره 2
خانم شهناز پولادي، آقاي احمد باقرپور برازجاني، خانم نيلوفر معتمد، آقاي عبداللطيف اميني، آقاي عليرضا رهبر، خانم حكيمه واحدپرست، خانم طيبه غريبي،
: امروزه، كاربرد داروهاي گياهي در كاهش ميزان چربي و قند خون با استقبال گسترده اي روبرو شده است. كاربرد گياه اسفرزه در درمان كلسترول خون بالا، نتايج ضد و نقيضي را ارائه داده است. مواد و روش ها: در يك كارآزمايي شاهددار تصادفي دوسويه كور، 72 نفر از افرادي كه داراي سطوح تري گليسيريد ميان 160 تا 200 ميلي-گرم در دسي ليتر و LDL كلسترول ميان 130 تا 190 بودند، در دو گروه مورد و شاهد به صورت تصادفي قرار گرفتند. در گروه مورد، روزانه 5 گرم پودر دانه گياه اسفرزه و به افراد شاهد نيز روزانه 5 گرم پودر سلولز داده شد كه به صورت ناشتا در آب حل نموده و ميل نمايند. پس از 60 روز، از هر دو گروه سطوح ليپيدهاي سرمي و قند خون ناشتا بررسي شد.
يافته ها: در سطوح تري گليسيريد تفاوتي در دو گروه ديده نشد، ولي سطح LDL كلسترول سرمي در هر دو گروه كاهش يافت ]به ترتيب ( 07/161 در مقايسه با 50/147 ميلي گرم در دسي ليتر در گروه اسفرزه؛ 002/0=P) و (80/156 در مقايسه با 10/132 ميلي گرم در دسي ليتر در گروه شاهد؛ 0001/0>P)[. در حالي كه HDL كلسترول تنها در گروه شاهد كاهش يافت (88/48 در مقايسه با 34/33 ميليگرم در دسي ليتر؛ 0001/0P).
نتيجه گيري: اسفرزه مي تواند LDL كلسترول سرمي را بدون اثر بر HDL كلسترول كاهش دهد.
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تاثير عصاره آبی گياه استويا ) Stevia rebaudiana ( بر ميزان سرمی واسپين و پروتئين
شبه آنژيوپويتين نوع 3 در موش هاي صحرايی ديابتی شده باسترپتوزوتوسين
طب جنوب
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Effect of intermittent fasting during Ramadan on Visfatin, Adiponectin and tumor necrotizing factor- alpha in healthy Muslim individuals
Journal of Fasting and Health
Volume 5, Issue 2, Spring 2017, Page 50-55
Eisa Safavi; Ali Reza Rahbar
دوم از 2 تفر
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Effect of Astaxanthin, Vitamin E, and Vitamin C in Combination with Calorie Restriction on Sperm Quality and Quantity in Male Rats.
J Diet Suppl.
2017 May 4;14(3):252-263.
PUBMED
Vahidinia A, Rahbar AR, Shakoori Mahmoodabadi MM.
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Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
2019;10(7)
Rahbar AR, Safavi E, Rooholamini M, Jaafari F, Darvishi S, Rahbar A
اول از شش نفر
Abstract
Background:
Insulin-like growth factor-1 (IGF-1) and interleukin-2 (IL-2) play an essential role in pathophysiology of several chronic diseases. As a stressor, fasting in Ramadan may increase inflammatory markers such as IGF-1 and IL-2 in Muslims. The aim of this before-after study was to investigate the effects of fasting in Ramadan on IGF-1 and IL-2 levels in individuals.
Methods:
In all, 34 men age 16-64 years were selected out of the overall number of individuals who were ready for fasting entirely throughout Ramadan. A sample of blood was drawn from the contributors before and after Ramadan, and plasma IGF-1, IL-2, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined. To identify differences between the initial and final values of test results of the study for plasma IGF-1, IL-2, and lipid parameters, we used paired sample T-test.
Results:
Paired sample T-test illustrated a significant decrease in IGF-1 and IL-2 levels after Ramadan fasting compared to before Ramadan. The concentration of TG, cholesterol, and LDL-C levels underwent significant decreases over the period of the study. HDL-C levels did not change significantly during the study. A significant decrease in weight, waist circumferences, calorie, carbohydrate, and fat intake were observed in participants during Ramadan fasting.
Conclusions:
It is concluded that fasting in Ramadan independent of anthropometric measures attenuates inflammation and is beneficiary to health.
KEYWORDS:
Fasting; insulin-like growth factor-1; lipids
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Bitter almond gum reduces body mass index, serum triglyceride, hyperinsulinemia and insulin resistance in overweight subjects with hyperlipidemia
Journal of Functional Foods
55
Chahibakhsh, N., Hosseini, E., lslam, M.S., Rahbar, A.R.
Abstract
The aim of this study was to compare the effects of different gums on glycemic and lipidemic parameters in patients with hyperlipidemia. Sixty patients were divided into four groups of 15 individuals in each group. Group 1 was selected as control. Groups 2,3, and 4 consumed 300 mL of apple juice enriched with bitter almond, tragacanth and xanthan gum, respectively. After 6-week intervention, the bodyweight, BMI, serum TG, hyperinsulinemia and HOMA-IR were significantly decreased in the subjects consumed bitter almond gum-enriched juice when no significant differences were observed for other parameters. The effect of bitter almond gum was better than tragacanth and xanthan gum in all parameters tested. The findings of this study suggest that some of the identified bioactive compounds in bitter almond gum might be responsible for its effects and it can be a possible food supplements for the better management of overweight, obesity and hyperlipidemia.
دریافت فایل پیوست
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Effects of Conjugated Linoleic Acid Intake in the Form of Dietary Supplement or Enriched Food on C-Reactive Protein and Lipoprotein (a) Levels in Humans: A Literature Review and Meta-Analysis
IRANIAN JOURNAL OF MEDICAL SCIENCES
2019; 44(5)
Derakhshandeh-Rishehri, SM ; Rahbar, AR; Ostovar, A
Abstract
Background: C-reactive protein (CRP) and lipoprotein (a) (Lp[a]) play essential roles in cardiovascular disease incidence. This study aimed to review the association between the intake of conjugated linoleic acid (CLA) in the form of dietary supplement or enriched food with different treatment durations and the levels of Lp(a) and CRP in human studies.
Methods: All the articles published in Cochrane Library, ProQuest, Scopus, and Google Scholar from November 2014 to October 2015 were searched and the clinical trials on the effects of CLA on Lp(a) and CRP levels were assessed. Of the 2249 articles initially retrieved, 21 eligible randomized clinical trials were enrolled in this systematic review. The publication dates of the eligible articles ranged from 2005 to 2013. The mean difference and the standard deviation of changes in CRP and Lp(a) levels in intervention and control groups were used as effect-size measures for meta-analysis. The obtained data from the eligible randomized controlled trials were meta-analyzed using Stata, version 13.
Results: The intake of CLA as a dietary supplement led to a significant increase in CRP levels (standardized mean difference [SMD]=0.41, 95% CI: 0.28 to 0.54; P=0.001). Subgroup analysis based on the duration of CLA consumption showed that CLA consumption more than 24 weeks resulted in a significant increase in the levels of CRP (SMD=0.52, 95% CI: 0.36 to 0.68; P=0.001) and Lp(a) (SMD=0.24, 95% CI: 0.01 to 0.47; P=0.04).
Conclusion: The current systematic review and meta-analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a).
Author Keywords:Conjugated linoleic acid; C-reactive protein; Lipoprotein (a); Meta-analysis
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